Sampling rates
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Please explain the difference between the sampling rates for distributions - particularly stage vs. trial.
If I choose to resample per Markov stage does it mean that all trials will have the same value per _stage?
If I choose to resample per individual trial will each trial have the same value across _stages?
Is there a way to resample per trial per stage such that, for example, the same drug has a different cost for each individual which varies every cycle?
Comments
Aliza
Distributions can be created for Probabilistic Sensitivity Analysis and Individual Microsimulation. Depending on what you are using the distribution for will determine which of the re-sampling rates you choose.
For distributions which are used for uncertainty (PSA) you would re-sample per EV.
For distributions which need to change for every individual - such as patient characteristics - you would re-sample per Trial. For example, a distribution for Age where each trial can have a different age would be sampled per Trial.
Lastly, distributions which you want to give a different value each Markov cycle select the re-sample per Markov Cycle. This is less common.
Can I encourage you to read the Help files, Chapter 20 specifically talks about many options for creating distributions.
If you have a very specific question, feel free to send it to support.
Thanks Belinda. I don't have a specific question in this case. I have read Chapters 20 and 21 but either missed the explanations or didn't understand them. For example, what does EV even stand for in this case? Expected Value?
I guess I am just asking for a recapitulation of the manual's explanation in simpler, more nuts-and-bolts terms.
EV refers to Expected Value. So when you sample a distribution "per EV", you are really sampling it once for each calculation of the model. This is appropriate for PSA.
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