Aggregation of scatter plot in PSA of microsimulation Markov model
I am now doing a CEA using the microsimulation Markov model. I used analysis->Monto Carlo Simulation->sampling (10,000) and trials (10,000). After having the results summary, I found that the ICE Scatterplot (AvsB) shows obvious aggregation. The variables, tables and their distributions have been checked without error. Besides, When doing the subgroup analysis, I found that all the incremental QALYs of the subgroup analysis were less than that for total sample analysis.
What is the possible problem with the model (or analysis)?
Thanks for any help!